Magnesium and Catalytic RNA

Bioinorganic Chemistry A Short Course, Second Edition, by Rosette M. Roat-Malone Copyright 2007 John Wiley Sons, Inc. 

Structure-function relationships were established for ribozymes by first considering how their tertiary structure must be dependent not only on the 

Important questions regarding the individual steps in the reaction mechanism were studied during the 1990s by substituting DNA (deoxy at the 2 -sugar 

I I I I I Watson-Crick pairs G-U wobble base pair /WWW exon 

In 2002, two particular areas of interest to the reference 1 author T. R. Cech were (1) interactions of proteins with ribozymes, as proteins enable or extend RNA activity and (2) solving structures of ribozymes at atomic resolution. As will be seen in the following paragraphs, both of these areas are still being addressed by researchers. 

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