Macular degeneration clinical presentation

Clinical presentation involves a normal postoperative course for several weeks to 6 months, followed by vision loss that is often the only symptom but may be accompanied by photophobia, injection, anterior chamber reaction, or Amsler grid distortion. There is some evidence of an increased prevalence of early age-related macular degeneration in eyes that have imdergone cataract surgery. Also, diabetic retinopathy and clinically significant diabetic macular edema may both be exacerbated by CE. Therefore the differential diagnosis of postoperative vision loss must include these conditions. 

For most photosensitizers used clinically at present for cancer treatment, and with surface irradiation, the typical energy densities required are around 100 J cm. The energy densities for some other treatments (e.g. macular degeneration or actinic keratosis) are much less, and some photosensitizers (e.g. mTHPC) require much less... 

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