Macular corneal dystrophy type

C-GlcNAc6ST Human 1 Macular corneal dystrophy type 1, II Loss of vision 50... 

Macular corneal dystrophy can be classified into three immunophenotypes, types I, lA, and II, according to the serum level of sulfated keratan sulfate and immunoreactivity of the corneal tissue. In macular corneal dystrophy type I, the keratan sulfate level is low in both the serum and corneal tissue. In macular... 

The keratan and chondroitin/dermatan sulfate levels in normal human corneas and corneas affected by macular corneal dystrophies types I and II were compared (10). The results revealed that the keratan sulfate chain size was reduced and chain sulfation was absent in type I, and that sulfation of both GlcNAc and Gal was significantly reduced in type II. The chondroitin/dermatan sulfate chain sizes were also decreased in all diseased corneas, and the contents of 4- and... 

Macular corneal dystrophy types I and II have also been characterized histo-chemically. In normal corneas, high levels of sulfated keratan sulfate were detected in the stroma. Bowman s layer, and Descemet s membrane with low levels in the keratocytes, epithelium, and endothelium. Furthermore, in normal corneas, negligible levels of labeling for A-acetyllactosamine (unsulfated keratan sulfate) were detected. In macular corneal dystrophy type I corneas, sulfated keratan sulfate... 

Lewis D, Davies Y, Nieduszynski lA, Lawrence F, Quantock AJ, Bonshek R, Fullwood NJ. Ultrastructural localization of sulfated and unsulfated keratan sulfate in normal and macular corneal dystrophy type I. Glycobiology 2000 10 305-312. 

Ouantock AJ, Fullwood NJ, Thonar EJ, Waltman SR, Capel MS, Ito M, Verity SM, Schanzlin DJ. Macular corneal dystrophy type II multiple studies on a cornea with low levels of sulphated keratan sulphate. Eye 1997 11 57-67. 

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