Macrophoma commelinae

An interesting example of biological insertion of carbon atoms C2 and C3 of pyruvic acid between C3 and C6 of pyrone rings (C3/C—C/C6) is performed by Macrophoma commelinae on methyl ether 26a and related... 

The phytopathogenic fungus, Macrophoma commelinae has the ability to transform 2-pyrone 146 into the corresponding benzoate analog macrophomate (152) (Scheme 27). This complex aromatic conversion is catalyzed by a single enzyme, with oxalacetate as a substrate for the C3-unit precursor. MPS is a... 

The first determined structure of a Diels-Alderase was that of the macrophomate-synthase of the phytopathogenic fungus Macrophoma commelinae (Fig. 5.158). 

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