Macromolecular recognition energetics

Robinson, C. R., S. G. Sligar, M. L. Johnson, and G. K. Ackers. 1995. Hydrostatic and osmotic pressure as tools to study macromolecular recognition. Energetics of Biological Macromolecules. 259, 395. 

In systems where the correlation holds, physical chemists can analyze the energetics of association and perform computer simulations of the recognition process based on this analysis. While still far from satisfactory, structure-based theoretical approaches to macromolecular recognition— another subject of our chapter—represent an active field of research with an important future in the postgenomic era. In a matter of years, large-scale efforts in protein structure determination are expected to provide... 

Biological Equilibria and Energetics. pH/bujfers, hinding/recognition, proton and electron transport, oxidation/reduction, macromolecular conformations. Some of these topics may be covered in laboratory courses. The experiments that are usedfor this purpose should emphasize techniques including error... 

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