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Macrocyclic kinase inhibitors CDKs

The design of a novel series of cycUn-dependent kinase (CDK) inhibitors with a macrocyclic quinoxaline-2-one 208 is reported (Kawanishi et al. 2006), where 208 was synthesized as shown in Scheme 5.50. The deprotonation of the fluorine-adjacent position of l-fluoro-2-iodobenzene 209, with LDA, followed by the carbon dioxide trapping and then esterification of the carboxylic acid, led to methyl 2-fluoro-3-iodobenzoate. The iodomagnesium exchange of methyl 2-fluoro-3-iodobenzoate according to Knochel s procedure (Knochel et al. 2003) followed by chloroglyoxylic acid ethyl ester resulted in ketoester 210, which was coupled with 3-[(tert-bulyldimethylsilyl)oxy]benzene-1,2-diamine to... [Pg.325]

Scheme 5.50 The sequence of the reactions for synthesizing cyclin-dependent kinase (CDK) inhibitors with a macrocyclic quinoxaline-2-one... Scheme 5.50 The sequence of the reactions for synthesizing cyclin-dependent kinase (CDK) inhibitors with a macrocyclic quinoxaline-2-one...
The macrocycle 208 is the inhibitor of the cylin-dependent kinase (Cdks) (Hirai etal. 2011). [Pg.327]

See other pages where Macrocyclic kinase inhibitors CDKs is mentioned: [Pg.16]    [Pg.166]    [Pg.177]    [Pg.176]    [Pg.192]    [Pg.196]    [Pg.198]    [Pg.216]    [Pg.623]    [Pg.102]    [Pg.178]    [Pg.179]   
See also in sourсe #XX -- [ Pg.157 ]



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