M-methoxybenzyl

Suggest a reasonable three step sequence showing all necessary reagents for the preparation of m methoxybenzyl cyanide from m methoxybenzaldehyde... 

Another quaternary anti arrhythmic agent is emilium tosyl-ate ( ). It is synthesized simply by quaternization of m-methoxybenzyl chloride (64) with dimethyl ethyl amine followed by ion exchange. 

The pre/ivference for solvolysis of meta substituted esters such as m-nitro-phenyl phosphate and m-methoxybenzyl acetate was discovered by Havinga et and studied further by Zimmerman (equation 50). Radicals can be formed in these reactions, and there is some dispute as to whether radical pairs also lead to ion pairs (equation 50). ... 

Disilamorpholines constitute another family of bioactive compounds. They have superior activity and are more easily prepared than their C-analogs. A series of compounds have been patented as muscle relaxants.506 4-(m-Methoxybenzyl)-l-oxa-4-aza-2,2,6,6-tetramethyl-2,6-disilacyclohexane, chosen for clinical muscle relaxant studies,479 was found to induce antifertility in male mammals (dogs). After administration of the drug (12-120 mg/kg daily) is stopped, their sperm count returns to normal and no evidence of testicular damage or aspermatogenesis is observed.507... 

An approach to the synthesis of B-norsteroids involves -alkylation of dienamine 65 with m-methoxybenzyl bromide and ring closure with H3P04 and P2Os53 (Scheme 34). The use of 2-(m-methoxyphenyl)allyl bromide gave access to 6-methyl- 19-norsteroids54. 

Martin, O R, Mahnken, R E, Intramolecular C-arylation of benzylated sugars. The unexpected double C-glycosidation of tn i -O-m-methoxybenzyl-p-D-ribofuranose derivatives, J. Chem. Soc., Chem. Commun., 497-498, 1986. 

In contrast, l-benzyl-6-m-methoxybenzyl-2(l//)-pyrazinone gave only 6-m-mcihoxybcnzyl-2(l//)-pyrazinone on reductive debenzylation (liquid NHj—THF, Na 49%). ... 

P-CH3O-C6H4CH2OH (p-methoxybenzyl alcohol) m-CH30-C6H4CH20H (m-methoxybenzyl alcohol) Carbonylation of 14.6.5.4.1. 

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