Lysosomes aminoglycoside nephrotoxicity

The exact mechanism of aminoglycoside nephrotoxicity is unclear. As discussed above, release of lysosomal enzymes can contribute to altered cellular function. Hydroxy radicals may also play a role in aminoglycoside mitochondrial effects, since catalase inhibits in vitro alterations of mitochondrial function by gentamicin and the use of hydroxy radical scavengers or iron chelators reduces gentamicin nephrotoxicity in vivo. Additionally,... 

Another class of catamphiphilic drugs with high toxic potential is the aminoglycosides. Their nephrotoxicity is manifested by lethal injury to the proximal tubular cells by means of the induction of renal cortical lysosomal phospholipidosis. The toxic effect involves three steps the uptake of the antibiotics into the cells, the intralysoso-mal lipid storage, and, finally, cell necrosis. The aminoglycosides are highly water... 

KojimaR, Ito M, Suzuki Y. Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects (4). Effects oftobramycin alone and in combination with latamoxef on the stability of rat kidney lysosomal membranes. Jpn J Pharmacol 1987 43(1) 73-80. 

---