Lysosome-vacuolar apparatus metabolic hydrolysis

CONTROL OF METABOLIC HYDROLYSIS IN THE LYSOSOME-VACUOLAR APPARATUS... 

The main purpose of this review is the identification and definition of the lysosome-vacuolar apparatus as it pertains to the control and regulation of intracellular metabolic hydrolysis. No attempt is made to review work devoted to the isolation, characterization or morphology of the lysosome-vacuolar system in mammalian cells. The reader is referred to earlier reviews (de Duve, 1963, 1968 NovikofiF, 1963 de Duve and Wat-tiaux, 1966 Verity, 1965) for detailed considerations of histochemistry, biogenesis, drug-lysosome interaction and pathological aspects pertaining to the lysosome concept. 

This review will define a simplified schematic model of the lysosome-vacuolar apparatus which will provide a framework for subsequent discussion on the control and modulation of metabolic hydrolysis. 

Of paramount importance to our subsequent discussion on the role, regulation and control of metabolic hydrolysis is an understanding of the morphological and biochemical substrate underlying the concept of the lysosomal-vacuolar apparatus. Central to this theme is the presence of an intracellular membrane-bound vacuolar system. The biochemically and morphologically defined entities of the lysosomal-vacuolar apparatusi... 

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