Lysine surfactant acylation

Lipase Amino acid surfactants Formation of amide bond between c-amine group of lysine and fatty acyl group Gardossi et al., 1991 Monlet et al., 1990 Soo et al., 2003... 

Most of the lysine-based surfactants are A -acyl lysine (Figure 5.3, 1) or A -acyl lysine (Figure 5.3, 2) salt or ester derivatives. 

Our group has aiready reported the physicochemical properties of Al -acyl lysine salts both as cationic surfactants and amphoteric derivatives [45] (Figure 5.3, 1). A -acyl... 

Biocompatible cationic surfactants from the amino acid lysine (hydrochloride salts of A -lauroyl-lysine methyl ester, IV -miristoyl-lysine methyl ester and A -palmitoyl-lysine methyl ester) show moderate antimicrobial activity against the Gram-positive bacteria. The haemolytic activity of these compounds is considerably lower than those reported for other cationic Ai -acyl amino acid analogues [64]. Taking into account the high biodegradation level and the low haemolytic activity, these compounds could be considered safe surfactants in relation to the cell of the human body. These properties make them suitable candidates for biological and medical applications [65]. 

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