Lynch syndrome risks

Lack of polyposis in Lynch syndrome appears like another logical consequence (1) There is no reason that at-risk people should develop more sporadic (RER —) adenomas than the general population (2) They are protected from the development of RER+ adenomas by apoptosis (3) Whenever a RER+ adenoma appears, it is difficult to observe because it degenerates so rapidly into a carcinoma. 

The proposed model of RER+ colorectal cancers suggests that the Lynch syndrome represents a new variation on the central theme of autosomal dominant cancer predisposition. Knudson s prediction of a shortened carcinogenesis among at-risk people applies to Lynch syndrome Sporadic RER+ CRCs exist and a subset of them have acquired mutations inactivating both alleles of a known MMR gene (B. Liu et al., 1995). On the other... 

Newell GR, Mansell PW, Wilson MB, Lynch HK, Spitz MR, Hersh EM (1985) Risk factor analysis among men referred for possible acquired immune deficiency syndrome. Prev Med 14 81-91... 

Women from families with hereditary ovarian cancer syndromes (i.e.. Lynch II syndrome) have a 40% lifetime risk... 

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