Lymphatics sustained drug release

Factors known to influence the clearance of drugs from interstitial sites, following extravasation or parenteral interstitial or transepithelial administration, include size and surface characteristics of particles, formulation medium, the composition and pH of the interstitial fluid, and disease within the interstitium. Studies indicate that soluble macromolecules smaller than 30 nm can enter the lymphatic system, whereas particulate materials larger than 50 nm are retained in the interstitial sites and serve as a sustained-release depot. The use of lipids or an oil in a formulation and the presence of a negative surface charge all appear to... 

Our studies related to biomedical applications of monosize polyalkylcyano-acrylate particles, such as in sustain release of pH sensetive drugs in GIT, diagnosis and therapy of inflammation, sintigraphy of lymphatic system with radiolabelled particles, are under investigation. 

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