Lymph nodes, spectra

Male and female mice exposed at concentrations up to 4mg/m 6 hours/day for 104 weeks had clear evidence of carcinogenicity based on increased incidences of alveolar/bron-chiolar neoplasms. In rats similarly exposed at concentrations up to 2 mg/m there was some evidence of carcinogenicity in male rats and equivocal evidence in females based on the occurrence of alveolar/bronchiolar neoplasms. Exposure to vanadium pentoxide also caused a spectrum of nonneoplastic lesions in the respiratory tract including alveolar and bronchiolar epithelial hyperplasia, inflammation, fibrosis, and alveolar histocytosis of the lung. Elyper-plasia of the bronchial lymph node occurred in female mice, and an unusual squamous metaplasia of the lung occurred in rats. ... 

Figure 9.2 Second derivative IR Spectra of lymph node tissue types. Trace A connective tissue of the lymph node capsule. The bands marked by asterisks are typical for collagen. Trace B spectrum observed for mixed tissues, containing collagen features peaks due to phospholipids found in fatty tissue. Traces C and D spectra of T- and B-lymphocytes, respectively. Traces E and F Spectra observed for the tumor areas. Trace E corresponds to the lighter blue area in Figure 9.1(c), whereas trace F corresponds to the darker, and more dense, areas of the tumor.

Rizzato G, Montemurro L. The chnical spectrum of the sarcoid peripheral lymph node. Sarcoidosis Vase Diffuse Lung Dis 2000 17 71-80. 

---