Luffariella variabilis

Phospholipase A2 Manoalide (Structure 16.5) majuscida Sponge, Luffariella variabilis Anti-inflammatory16... [Pg.524]

However, clinical studies on marine metabolites are often hampered by insufficient supply of material, as it was reported for dolastatin 10 from the sea hare Dolabella auricularia [107]. In the case of manoalide, obtained from the sponge Luffariella variabilis, it remains open whether its use will be restricted to an application in studying inflammatory processes on the cell level or whether it... [Pg.119]

Scheme 13. Structures of the sesteiterpenes luffariellin A [1], luffariellin B [2], manoalide [3], secomanoalide [4] from Luffariella variabilis, thorectolide monoacetate [5] from Thorectandra excavatus.

Luffalactone (95) from the Pacific Luffariella variabilis is a sesterterpene with a labdane type skeleton, related to manoalide (53). Luffalactone showed 52% inhibition of oedema in the mouse ear assay at 50 pg/ear [87],... [Pg.132]

Manoallde. C2jH3603, Mr 416.56, amorphous solid, as 25-acetate mp. 117 -119 °C. A sesterterpenoid marine natural product from the sponge Luffariella variabilis, the name is derived from the Manoa valley, Oahu, Ha-... [Pg.379]

De SUva, E.D., Scheuer, P.J., 1980. ManoaUde, an antibiotic sesterterpenoid from the marine sponge Luffariella variabilis. Tetrahedron 21,1611-1614. [Pg.146]

Luffariella variabilis provided four sesterterpenoid antibiotics (159-162) (117, 118). Manoalide (159) which contains an a,P-unsatu-rated 5-lactol function was without close structural analogy. 160 was an open chain isomer of 159, with -configuration of the C-6,7 double bond which prevents ring closure between the C-24 aldehyde and the... [Pg.171]

De Silva, E.D., and P.J. Scheuer Manoalide, an Antibiotic Sesterterpenoid from the Marine Sponge Luffariella variabilis (Polejaeff). Tetrahedron Lett. 21, 1611 (1980). [Pg.326]

Manoalide (ACN-190093) Phase II Luffariella variabilis Anti-psoriasis Terpene... [Pg.48]

Gauvin, A., Smadja, J., Aknin, M., Faure, R., and Gaydou, E.M. (2000) Isolation of bioactive 5a,8a-epidioxy sterols from the marine sponge Luffariella( . variabilis. Can.]. Chem., 78, 986-992. [Pg.1197]

Motti, C.A., Fttinger-Fpstein, P., Willis, R.H., and Tapiolas, D.M. (2010) ESI FTIR-MS analysis of larvae from the marine sponge Luffariella variabilis. Mar. Drugs, 8, 190-199. [Pg.1251]

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