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Luciferase, discovery

The luciferin-luciferase reaction of fireflies was first demonstrated by Harvey (1917), although the light observed was weak and short-lasting. Thirty years after Harvey s discovery, McElroy (1947) made a crucial breakthrough in the study of firefly bioluminescence. He found that the light-emitting reaction requires ATP as a cofactor. The addition of ATP to the mixtures of luciferin and luciferase... [Pg.3]

Following the discovery of luciferin and luciferase by Dubois, the person who made the greatest contribution to the knowledge of... [Pg.487]

Discovery of luciferin-luciferase reaction Benzoylation of Cypridina luciferin ATP requirement in firefly luminescence Requirement for long-chain aldehyde (luciferin) in bacterial luminescence... [Pg.491]

To increase content recovery, a biochemical component that complements the luciferase reporter-based readouts is incorporated in the overall drug discovery platform. The following protocol describes how the lysate from a single 96-well plate is transferred to nitrocellulose for Western blotting using a 96-well dot-blotting device (a dot blotter). [Pg.10]

Multiplexed Luciferase Reporter-Based Approaches to Drug Discovery... [Pg.11]

See other pages where Luciferase, discovery is mentioned: [Pg.18]    [Pg.31]    [Pg.95]    [Pg.235]    [Pg.250]    [Pg.324]    [Pg.490]    [Pg.491]    [Pg.185]    [Pg.630]    [Pg.404]    [Pg.40]    [Pg.746]    [Pg.369]    [Pg.630]    [Pg.151]    [Pg.548]    [Pg.118]    [Pg.251]    [Pg.254]    [Pg.695]    [Pg.241]    [Pg.124]    [Pg.3]    [Pg.57]    [Pg.186]    [Pg.186]    [Pg.21]    [Pg.13]    [Pg.44]   
See also in sourсe #XX -- [ Pg.4 ]



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Luciferases

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