Low dose, high resolution

Pan M, Crozier PA (1993) Low-dose high-resolution electron-microscopy of zeolite materials with a slow-scan CCD camera. Ultramicroscopy 48 332-340... 

In patients with ILD, the low-dose high-resolution CT technique with a reduction of the miUiampere-second values to approximately 40 mAs is in our view a valuable alternative to the standard volumetric protocol when combined with the sequential HRCT technique. It allows for the assessment of... 

Miller A, Markowitz S, Manowitz A, Miller JA (2004) Lung cancer screening using low-dose high-resolution CT scanning in a high-risk workforce. Chest 125 1525-1535... 

Jamali, B., and Lehmann, S. (2004). Development and validation of a high-resolution capillary electrophoresis method for multi-analysis of ragaglitazar and arginine in active pharmaceutical ingredients and low-dose tablets. /. Pharm. Biomed. Anal. 34(3), 463—472. 

Because clozapine may block specific DA receptors, its antipsychotic activity could be consistent with an antidopaminergic mechanism of action. Conversely, clozapine does not typically induce extrapyramidal symptoms, which are presumably subserved by the A-9 system. Thus, while clozapine is known to block striatal DA receptors, in positron emission tomography (PET) studies, resolution is not sufficient to clarify effects on other tracts. Furthermore, low doses of metoclopramide, which significantly decrease the number of DA neurons spontaneously active in A-9, do not have antipsychotic effects (except at high doses) but can induce tardive dyskinesia (TD), as well as acute extrapyramidal side effects (EPS). 

X-ray crystal stmcture of hydroperoxo-ferric complex in CPO was determined as a result of cryogenic photoreduction of oxy-ferrous precursor during data collection in the synchrotron beam.133 Three data sets with low, medium, and high dose have been prepared from the data collected on multiple crystals with the goal to resolve the structures with well-defined redox state. Because of the fast reduction, the low-dose data set already had sufficient contribution of Compound 0, and the stmcture of Compound III could not be determined. The medium-dose data set was resolved to 1.75 A resolution and revealed a well-defined 0-0 ligand with 100% occupancy. Assignment of this stmcture to hydroperoxo- ferric versus peroxo-ferric was done based on the QM/MM calculation. 

Martin et alJ106b have employed low-dose techniques to obtain selected area electron diffraction and high-resolution electron microscopy of these phenylacetylene dendrimer s. 

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