LoVo tumor cell

Twenty-five cryptophycins, e.g. cryptophycin 1 (162), have been isolated from a Nostoc sp. strain. They exhibit various degrees of cytotoxicity against three tumor cell lines, namely KB (human nasopharyngeal), LoVo (human colorectal adenocarcenoma), and SKOV3 (human ovarian carcinoma). Removal of the chlorine atom leads to a 10-fold reduction in cytotoxicity [124]. The antitumor activity of a number of cryptophycins from Nostoc sp. has been evaluated [125]. 

In an attempt to evaluate cytotoxic activity against tumor cell lines, the navirine B (9) was found active against colon and ovarian cell lines (LoVo and 2008, respectively) while chellespontine (11) was active only against LoVo cells (DalFAcqua et al., 2008). 

These compoimds were also tested in vitro against LoVo (human colon adenocarcinoma) and LoVo/DX cells in comparison with DOXO. The results showed that these derivatives were less potent than the natural drug on the sensitive tumor. While they were more potent on DOXO-resistant cells. Nevertheless, these compounds aroused only academic interest [8]. 

NCX 4040, 2-(acetyloxy)benzoic acid 4-(nitrooxy-methyl)phenyl ester, combined with either oxaliplatin or 5-FU significantly inhibited tumor growth, prolonged delays in tumor growth, and increased apoptotic indexes compared with those treated with oxaliplatin alone in xenograft models using the three human colon cancer cell lines (WiDr, LoVo, and LoVoDx) (Leonetti et al. 2006). 

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