Losartan Erythromycin

P-gp (ABCB1) Verapamil, digoxin, mitoxantrone, vinblastine, doxorubicin, losartan, talinolol, cortisol, dexamethasone, colchicine, loperamide, domperidone, indinavir, erythromycin, tetracycline, itraconazole, cyclosporine, methotrexate, amitryptyline, phenobarbital, morphine, cimetidine, and others... 

Williamson KM, Patterson JH, McQueen RH, Adams KF Jr, Pieper JA. Effects of erythromycin or rifampm on losartan pharmacokinetics in healthy volunteers. Clm Pharmacol Ther 1998 63(3) 316-23. 

Acetaminophen, aldrin, alfentanil, amiodarone, aminopyrine, amitriptyline, amprenavir, androstenedione,antipyrine, astemizole, benzphetamine, budesonide, carbamazepine, celecoxib, chlorpromazine, chlorzoxazone, cisapride, clarithromycin, clozapine, cocaine, codeine, cortisol, cyclophosphamide,cyclosporin, dapsone, delavirdine, dextromethorphan, digitoxin, diltiazem, diazepam, erythromycin, 17j3-estradiol, ethinylestradiol, etoposide, felbamate, fentanyl, flutamide, hydroxyarginine, ifosphamide, imipramine, indinavir, ketoconazole, lansoprazole, loratidine, losartan, lovastatin, (iS)"mephen3d in, methadone, mianserin, miconazole, mifepristone, nelfinavir, nevirapine, nicardipine, nifedipine, odansetron, omeprazole, orphenadrine, proguanil, propafenone, quinidine, quinine, rapamycin, retinoic acid, ritonavir, saquinavir, selegiline, serindole, sufentanil, sulfinpyrazone, tacrolimus, tamoxifen, tamsulosin, taxol, teniposide, terfenadine, tetrahydrocannabinol, theophylline, toremifene, triazolam, trimethadone, trimethoprim, troleandomycin, verapamil, warfarin, zatosetron, Zolpidem, zonisamide... 

CYP3A4 Amitryptiline, Imipramin, Cyclosporine, Docetaxel, Epipodophyllotoxin, Erythromycin, Losartan, Diazepam, Carbamazepine, Nefadozone, Nifedipine, Omeprazole, Terfenadine, Chlorpyrifos (Insecticide), Testosterone, Estradiol, Progesterone, and synthetic sexual steroids... 

Parnell K, Rodgers J, Graff D, Allen T, Hinderliter A, Patterson J, Pieper J. Inhibitory effect of fhicona le and erythromycin plus fluvastatin on losartan disposition in normal volunteers. ClinPharmacolTlKr(2000) 67, 121. 

The pharmacokinetics and blood pressure-lowering effect of losartan do not seem to be affected by erythromycin. 

When 10 healthy subjects were given losartan 50 mg daily for a week and then, after a 6-day washout period, losartan 50 mg daily with erythromycin 500 mg four times daily for a week, it was found that erythromycin had no significant effect on the pharmacokinetics of losartan or its active metabolite, E-3174. In addition, erythromycin did not alter the blood pressure-lowering effect of losartan. Inhibition of the cytochrome P450... 

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