Long-term potentiation , kainate

Long-term potentiation and depression of glutamatergic synapses are involved in many models for brain function and development. A key factor in the plasticity is a change in the AMPA and kainate... 

Durand GM, Kovalchuk Y, Konnerth A (1996) Long-term potentiation and fimctional synapse induction in developing hippocampus. Nature 381 71-75 Eder M, Becker K, Rammes G, et al (2003) Distribution and properties of functional postsy-naptic kainate receptors on neocortical layer V pyramidal neurons. J Nemosci 23 6660-... 

In the hippocampus, the mossy fiber synapses onto CA3 pyramidal neurons are characterized by a particularly high degree of synaptic plasticity. On a short-term time scale in the range of seconds, one can observe pronounced paired pulse as well as frequency facilitation. The latter phenomenon reflects a multifold increase in synaptic strength when the stimulation frequency is enhanced and involves activation of presynaptic kainate autoreceptors (Schmitz et al. 2001). On a longer time scale in the range of minutes, one can observe long-term potentiation (LTP). At the mossy fiber synapses, LTP is independent of NMDA receptors, but there is sufficient... 

Bortolotto, Z. A., Lauri, S., Isaac, J. T., and Collingridge, G. L. (2003). Kainate receptors and the induction of mossy fibre long-term potentiation. Trans. R. Soc. Land. B Biol. Sci. 358, 657-666. 

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