Long-term exposure and carcinogenicity

Antitumour activity has been reported for alkyltins, particularly dibutyltin. The effect in mouse skin initiation/promotion protocols showed dibutyltin inhibiting the promotion stage (Arakawa Wada, 

Toxicity studies described in sections 8.3 and 8.4 are summarized in Table 22, where studies used to derive medium-term exposure TDIs (see section 11.1.2) are also indicated. 

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