Loeffler’s syndrome

Drugs That Induce Pulmonary Infiltrates with Eosinophilia (Loeffler s Syndrome)... 

Allergic pneumonitis and transient eosinophihc pulmonary infiltrate (Loeffler s syndrome) are rare. These syndromes have also been observed with peniciUin hypersensitivity (14-16). In one case, an alveolar allergic reaction, probably due to ampicillin, showed features of an adult respiratory distress syndrome (17). 

Reichhn S, Loveless MH, Kane EG. Loeffler s syndrome following penicillin therapy. Ann Intern Med 1953 38(l) 113-20. 

Pulmonary infiltrates with eosinophilia (Loeffler s syndrome) have been associated with nitrofurantoin,para-aminosalicytic acid, methotrexate, sulfonamides, tetracycline, chlorpropamide, phenytoin, NSAIDs, and imipramine (Table 29-5). The disorder is characterized by fever, nonproductive cough, dyspnea, cyanosis, bilateral pulmonary infiltrates, and eosinophilia in the blood. Lung biopsy has revealed perivasculitis with infiltration of eosinophils, macrophages, and proteinaceous edema fluid in the alveoli. The symptoms and eosinophilia generally respond rapidly to withdrawal of the offending drug. 

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