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Loading tests, metabolic histidine

The histidine load test is not used in the clinical setting and is only sometimes used by researchers however, a description of this test provides a clear-cut example of how folates behave in the mediation of 1-carbon metabolism. Histidine catabolism takes place in the liver according to the pathway sho vn (Figures 9.16 and 9.17). The intermediates, formiminoglulamic acid and j-forrnirnino-H folate, bear the formimino group —CH hJH. [Pg.509]

Abnormal response to a metabolic load, such as the inability to metabolize a test dose of histidine in folate deficiency (Section 10.10.4), or tryptophan in vitamin Be deficiency (Section 9.5.4), although at normal levels of intake there may be no metabolic impairment. [Pg.11]

Although the FIGLU test depends on folate nutritional status, the metabolism of histidine wUl also be impaired and a positive result obtained, in vitamin B12 deficiency, because of the secondary deficiency of folate (Section 10.3.4.1). About 60% of vitamin Bi2-deficient subjects show increased FIGLU excretion after a histidine load. [Pg.317]


See other pages where Loading tests, metabolic histidine is mentioned: [Pg.923]    [Pg.156]    [Pg.246]   
See also in sourсe #XX -- [ Pg.316 ]

See also in sourсe #XX -- [ Pg.316 ]

See also in sourсe #XX -- [ Pg.316 ]




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