477-lmidazoles

Ethyl 4,5-Dlbenzamldopent-4-enoate (2) Ethyl 3-lmidazol-4(5)-ylpropanoale 1 (9.2 g, 54 mmol) In ElOAc (140 mL) was treated with benzoyl chloride (15 7 g, 112 mmol) In ElOAc (40 mL) and 1M NaHCOa (380 mL) added simultaneously In 1 h under Ice-cooling. The reaction mixture was stirred for 1 h, then a further portion of benzoyl chloride (IS 7 g, 112 mmol) in ElOAc) and iM NaHCOa (280 mL) was added m the same manner, followed by an additional portion o( 1M NaHCOa (200 mL) The reaction mixture was stirred for 24 h, then the organic layer was separated, concentrated, and the residue dissolved in THF (300 mL) The THF solution was stirred with 10% NaHCOa (600 mL) for 24 h to decompose any N-lormyl intermediate and to remove benzoic acxl Extraction with EtOAc, drying (Na2S04), solvent evaporation and recrystallization of the residue from EtOAc hexane afforded 16 24 g of 2 (84%), mp 128-129°C... 

I 3 Regulation of Cene Expression with Pyrrote-lmidazole Polyamides... 

The Hedrick and Waymouth groups have also studied methods for generating NHC catalysts in situ for ROP without an external base [147-150], Thermal generation occurs readily with chloroform adduct 295 and pentafluorophenyl adduct 296 [147, 149]. Both compounds perform well as polymerization catalysts although 296 is stable at room temperature unlike 295. (lmidazol-2-ylidene)... 

N-Methylimidazole Imidazole, 1-methyl- (8) IH-lmidazole, 1-methyl (9) (616-47-7) 1-Chlorobutane Butane, 1-chloro- (8,9) (109-69-3)... 

Nucleophilic Displacement Reactions of lmidazole-1-Sulfonate Esters... 

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