Liver plasma enzyme activity carboxylesterases

The term carboxylesterase refers to a wide variety of enzymes with both esterase and amidase activity. They cleave carboxylesters, carboxylamides, and car-boxylthioesters, producing a carboxylic acid and an alcohol or phenol (Figure 8), amine, or mercaptan, respectively. There are many different esterases, some of which are important for the hydrolysis and detoxication of toxic organophosphate esters. In general, esterases are present in almost all mammalian tissues, occur as multiple isozymes, and are concentrated in the liver. The esterase activity present in plasma is normally due to the release of these enzymes from liver. 

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