Liver metal accumulation

Liver damage due to copper at low Mo (20 mg/kg) diets at 40 and 60 mg Mo/kg, both metals accumulated in kidney cortex but no evidence of liver histopathology or kidney damage (18)... 

In certain human pathologies, as well as in experimental animals, aluminum has been observed to accumulate preferentially inside lysosomes. The experimental evidence raised the possibility that lysosomes serve as an elective site of metal accumulation. Lysosomes might thus protect the rest of the cell from toxic effects produced by free metals or metal compounds. As reported by Zatta et al. [39] aluminum is able to inhibit the lysosomal H+ ATPase activity from rat liver. Intralysosomal pH is acidic, and it is accepted that it is maintained by the proton pump which is an enzyme activated by... 

In the experimental animal, renal damage is not a normal response to a single acute dose of cadmium since, under these conditions the metal accumulates predominantly in the liver and kidney uptake is small. It is possible, however, to alter the distribution of cadmium between these organs by administration of a suitable chelating agent simultaneously with the metal. Thus the injection of 10 ymol CdCl2 together with excess cysteine results in a renal concentration within... 

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