Liver failure laboratory findings

Abnormal clearance may be anticipated when there is major impairment of the function of the kidney, liver, or heart. Creatinine clearance is a useful quantitative indicator of renal function. Conversely, drug clearance may be a useful indicator of the functional consequences of heart, kidney, or liver failure, often with greater precision than clinical findings or other laboratory tests. For example, when renal function is changing rapidly, estimation of the clearance of aminoglycoside antibiotics may be a more accurate indicator of glomerular filtration than serum creatinine. 

The clinical and laboratory findings of this sudden deterioration largely correspond to those of acute liver failure (see above). This also applies to potential complications such as coagulopathy, HE, ascites and/or HRS. 

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