Liver, as an excretory organ

Because of the similar behavior of injected alkaline phosphatase and albumin, it becomes unnecessary to consider the liver as an excretory organ for serum alkaline phosphatase to any greater extent than it is required to excrete albumin, which has never been considered a significant process. 

There are, however, some particular conditions which point to a drug or chemical causation. Hepatitis is one such condition, and it can easily be seen that the liver can be a target because of its part in the metabolism, conjugation and excretion of chemicals. The kidney seems to be at much less risk as an excretory organ alone, nevertheless renal damage by drugs is more common than heart or lungs, for example. 

This organ plays a central role in the physiopathology of alkaline phosphatase (B9, C2, D4, D5, M21, Nl, P2, R6, S7, S26, S28, S29). Over the years the prevailing concept has been that the liver s function is an excretory one insofar as serum alkaline phosphatase coming to the liver is concerned, the source of the enzyme being osseous. Now, one part of this view has been challenged by Posen, who states that the liver does not excrete alkaline phosphatase and that hyperphosphatasemia owes to regurgitation of bile ducts (B20). 

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