Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Lithium, 2- pheny

A Indole, when treated with one equivalent of sodaniide and then with benzenesulfonyl chloride, gives l- pheny sutronyl)indole. The A -sulfonyl substituent activates the H-2 to deprotonation by butyl-lithium and stabilizes the lithium derivative by chelation. This oriho lithiation process facilitates subsequent acetylation at this site by acetyl chloride, affording 2-acetyl-l-(phenylsulfonyl)indole (Scheme 7,11). [Pg.104]

The most versatile lithium amides in regard to accessibility and asymmetric induction in deprotonation and elimination reactions arc lithium bis(l-phenylethyl)amide, lithium 2,2-dimethyl-A -[1 -pheny 1-2-0-piperidinyliethyljpropylamide and lithium 2,2-dimethyl-A-[2-(4-methyl-l-piperazinyl)-l-phenylethyl]propylamide. 1-Phenylethylamine and phenylglycine, which serve as educts for the synthesis of these bases, are commercially available at modest prices in both enantiomeric forms. Relevant preparative procedures can be found in the Appendix. [Pg.589]

Asymmetric deprotonation of monocyclic cycloalkanones is not restricted to cyclohexanones. Thus, deprotonation of 3-phenylcyclobutanone with lithium bis[(S)-l-phenylethyl]amide in THF at — 100 °C in the presence of chlorotriethylsilane affords (—)-(/ )-3-pheny 1-1 -(triethylsi-lyloxy)-l-cyclobutene with 92% ee in 70% yield59d. Interestingly, with lithium (/ )-2,2-dimethyl-A-[( / )-2-(4-methyl-l-piperazinyl)-l-phenylethyl]propylamidc in THF/HMPA an ee value of only 47 % for the enol ether is recorded. [Pg.603]

Lithium diallylcuprate, 11 Lithium dibutylcuprate, 61 Lithium dimethylcuprate, 63, 258 Sakurai reaction Alkylaluminum halides, 5 Allyltrimethylsilane, 11, 305 Titanium(IV) chloride, 304 with other organometallic agents (IS, 2S) -2-Amino-3-methoxy-1 -pheny 1-1-propanol, 17... [Pg.361]

A first series was reported on the reaction of simple aryl lithium species with 6-(V,(V-dimethylamino fulvene and subsequent transmetallation. Thereby, it was possible to synthesise para-methoxy phenyl (15), /V./V-di methyI -pheny I (16) and benzo[l,3]dioxole phenyl-substituted (17) dimethylamino-functionalised titanocene dichlorides, which show IC50 values in the range of 54 pM [22]. This represents a significant improvement in cytotoxicity compared with the benzyl-substituted titanocenes by a factor of 3 for titanocene 16 (IC50 for the benzyl-substituted analogue 120 pM) and even 10 for titanocene 17 (IC50 for the benzyl-substituted analogue 280 pM). The sole decrease in cytotoxic activity was... [Pg.126]

Pheny 1-2/7-1,3-ditellurole was lithiated in the 2-position by lithium diisopropylamide. The 2-lithioditellurole reacted with 0-deuteromethanol, methyl iodide, and with benzalde-hyde, and decomposed at temperatures above — 70°. It did not react with trimethylchl-orosilane at — 70°, however, at — 20° tellurium was precipitated with formation of phenyl(trimethylsilyl)-ethene . [Pg.799]

Interactions. Several types of drug interfere with lithium excretion by the renal tubules, causing the plasma concentration to rise. These include diuretics (thiazides more than loop type), ACE inhibitors and angiotensin-11 antagonists, and nonsteroidal anti-inflammatory analgesics. Theophylline and sodium-containing antacids reduce plasma lithium concentration. The effects can be important because lithium has such a low therapeutic ratio. Diltiazem, verapamil, carbamazepine and pheny-toin may cause neurotoxicity without affecting the plasma lithium. Concomitant use of thioridazine should be avoided as ventricular arrhythmias may result. [Pg.391]

The present procedure starts with ethyldiphenylphosphine, which is cleaved by lithium in tetrahydrofuran to lithium ethylphenylphosphide. This phosphide under vigorous reflux cleaves tetrahydrofuran to afford a necessary precursor, 4-(ethylphenylphosphino)-1 -b utanol (ethyl(4-hydroxybutyl)pheny Iphosphine). This(hydroxyalkyl)phosphine then is cyclized intramolecularly to give 1-ethyl-l-phenylphospholanium perchlorate. [Pg.189]

Pheny(acetylenes (3 mol) react with Te02 (1 mol) and excess of lithium halide in refluxing HOAc to produce 3-halobenzotellurophenes via the addition of a Te(IV) acetate halide to the triple bond, cyclization (probably by loss of HOAc) and reduction of the Te(IV) cyclic product to 3-halobenzotellurophene by an excess of the pheny(acetylene. Owing to isolation facilities, the product is converted into the crystalline dichlorides that is reduced to the benzotellurophenes. ... [Pg.292]

WITTIG-HORNER REACTION Diethyl isocyanomethylphophonate. Diethyl lithiodichlo-romethanephosphonate. Diethyl phenylsulfinylmethylphosphonate. Diethyl phenyl-thiomethanephosphonate. Diethyl phosphorylmethyl methyl sulfoxide. Lithium di-pheny Ipho sphide. [Pg.792]

Both Jlic and Jun couplings have been observed by Sott et alP in the spectra of isotopically labelled mixed complexes formed by the lithium salt of acetonitrile (LiCH2CN) and the chiral lithium amides, Li-([Pg.168]

Bis-(3-dimethylaminopropyl)pheny Iphosphine/ lithium bromide Ketones from thiolic acid esters /I-Diketones... [Pg.258]

When a methoxy group resides at the lithium-bearing carbon, it coordinates the metal and assists its delivery to the other end of the backbone. Dissolved in pentanes (48 h at +20 °C), DEE (5 h at -40 °C), or THE (0.5 h at -75 °C), 1-methoxy-1-pheny 1-5-hexenyllithium, while crossing the transition state 138 (Scheme 1-101), produces a sole stereoisomer. ... [Pg.77]


See other pages where Lithium, 2- pheny is mentioned: [Pg.622]    [Pg.443]    [Pg.323]    [Pg.383]    [Pg.586]    [Pg.376]    [Pg.191]    [Pg.398]    [Pg.150]    [Pg.65]    [Pg.195]   
See also in sourсe #XX -- [ Pg.3 , Pg.47 , Pg.62 ]




SEARCH



5- -3-pheny

© 2024 chempedia.info