Lithium diisopropylamide properties

Lithium dichromate, molecular formula, properties, and uses, 6 562t Lithium diisopropylamide (LDA), 15 148 Lithium-drifted silicon [Si(Li)] detector, 26 434... 

Lithium diisopropylamide (LDA) is easily prepared by reaction betweea butyliithium (BuLi) and diisopropyiamine and is widely used as a base fin preparing enolate ions from carbonyl compounds. LDA has nearly ideal properties ... 

Stronger bases, such as amide anion, methylsulfinylcarbanion (the conjugate base of dimethyl sulfoxide), and triphenylmethyl anion, are capable of effecting rapid and essentially complete conversion of a ketone to its enolate. Lithium diisopropylamide, generated by addition of Ai-butyllithium to diisopropylamine, is widely used for this purpose. It is a very strong base, yet is sufficiently bulky so as to be relatively nonnucleophilic—a feature that is important in reducing a number of side reactions. The lithium and sodium salts of hexamethyldisilazane [(CH3)3Si]2NH are easily prepared and handled compounds with properties similar... 

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