Lithium calcitonin

Mathe AA, Jousisto-Hanson J, Stenfors C, et al Effect of lithium on tachykinins, calcitonin gene-related peptide, and neuropeptide Y in rat brain. J Neurosci Res 26 233-237, 1990... 

In four women serum lithium concentrations fell significantly within 3 days of starting calcitonin (23) because of increased renal clearance of lithium (23,24). Serum lithium concentrations should therefore be monitored in patients who start to take calcitonin. 

Serum lithium concentration should be monitored at the start of calcitonin therapy. 

After they had received 100 units of salmon calcitonin subcutaneously for 3 days, four patients had a 30% mean reduction in serum lithium concentration, which was attributed to reduced absorption and/or increased renal excretion (23). 

Passiu G, Bocchetta A, Martinelli V, Garau P, Del Zompo M, Mathieu A. Calcitonin decreases lithium plasma levels in man. Preliminary report. Int J Clin Pharmacol Res 1998 18(4) 179-81. 

Bachofen M, Bock H, Beglinger C, Fischer JA, Thiel G. Calcitonin, ein proximal tubular wirkendes Diuretikum Lithium-Clearance-Messungen am Menschen. [Calcitonin, a proximal-tubular-acting diuretic lithium clearance measurements in humans.] Schweiz Med Wochenschr 1997 127(18) 747-52. 

A 4-tosyl ester has been prepared in 70-80% yield from a phenol (human calcitonin) in 0.02M lithium carbonate at pH 10-11.5 by the use of the reagent... 

A study in 4 depressed women found that calcitonin (salcatonin) caused a small reduction in serum-lithium levels, the clinical importance of which is not known. 

Prompted by the oeeasional observation of decreased serum-lithium levels in outpatients receiving calcitonin, a study was undertaken in 4 bipolar depressive women. The patients, who had been stable on lithium for 10 years, were additionally given salmon calcitonin (salcatonin) 100 units subcutaneously for 3 consecutive days for postmenopausal osteoporosis. It was found that their serum-lithium levels fell, on average, from 0.73 to... 

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