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Lithium aluminum hydride chiral alkoxy derivatives

In 1951 Bothner-By first attempted asymmetric reductions based on the conversion of lithium aluminum hydride (LAH) into a chiral alkoxy derivative by reaction with (+)-camphor. Since this pioneering work, the use of chirally modified LAH reagents has been the focus of much attention. In 1979, the first virtually complete enantiofacial recognition of prochiral carbonyl compounds was accomplished by using LAH modified with optically pure 2,2 -dihydroxy-1,1 -binaphthyl and a simple alcohol (BINAL-H). Asymmetric reduction with chiral 2,5-dimethylborolane also gave alcohols in high optical yields." Recently, excellent results have been obtained using a chirally modified sodium borohydride... [Pg.159]




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Alkoxy aluminum hydrides

Alkoxy chiral

Alkoxy derivatives

Aluminum derivatives

Chiral derivatives

Chiral hydride

Hydride derivatives

Lithium aluminum hydride derivatives

Lithium derivatives

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