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Lissoclin disulfoxide

Table 4.9 Inhibition of CXCBl, CXCR2, and PKCot with Frondosins A and C, and Lissoclin Disulfoxide... Table 4.9 Inhibition of CXCBl, CXCR2, and PKCot with Frondosins A and C, and Lissoclin Disulfoxide...
One of the invertebrates collected during the 1994 SIO-RU-SKB collaborative marine invertebrate collection from the Aliwal Shoal off southern Kwazulu-Natal, South Africa was the ascidian Lissoclinum sp.. Bioassay guided fractionation of a methanol extract of this ascidian yielded a novel interleukin-8 inhibitor, lissoclin disulfoxide (88) [84], Interleukin-8 (IL-8), a promoter of neutrophil aggregation and activation, is implicated in a wide range of inflammatory disorders e.g. psoriasis and rheumatoid arthritis [85]. In addition to its potent inhibition of both IL-8 Roc and IL-8 R(3 (IC50 = 0.6 and 0.82 pM respectively) 88 also exhibited activity against the protein kinase C enzyme (IC50 = 1.54 pM) [84]. [Pg.87]

See other pages where Lissoclin disulfoxide is mentioned: [Pg.636]    [Pg.834]    [Pg.835]    [Pg.863]    [Pg.87]    [Pg.636]    [Pg.834]    [Pg.835]    [Pg.863]    [Pg.87]   
See also in sourсe #XX -- [ Pg.834 , Pg.863 ]

See also in sourсe #XX -- [ Pg.4 , Pg.163 ]

See also in sourсe #XX -- [ Pg.163 , Pg.164 ]

See also in sourсe #XX -- [ Pg.25 , Pg.834 , Pg.863 ]

See also in sourсe #XX -- [ Pg.87 ]



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