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Liquid chromatography solvent gradient

The popularity of reversed-phase liquid chromatography (RPC) is easily explained by its unmatched simplicity, versatility and scope [15,22,50,52,71,149,288-290]. Neutral and ionic solutes can be separated simultaneously and the rapid equilibration of the stationary phase with changes in mobile phase composition allows gradient elution techniques to be used routinely. Secondary chemical equilibria, such as ion suppression, ion-pair formation, metal complexatlon, and micelle formation are easily exploited in RPC to optimize separation selectivity and to augment changes availaple from varying the mobile phase solvent composition. Retention in RPC, at least in the accepted ideal sense, occurs by non-specific hydrophobic interactions of the solute with the... [Pg.202]

The remainder of this section deals primarily with selectivity optimization in isocratic liquid chromatography and with gradient elution Before entering these subjects proper, however, a discussion of the relevant chromatographic properties of solvents is in order as a framework for the intuitive selection of the preferred solvent or solvent mixtures for selectivity optimization. [Pg.234]

Temperature-programmed packed capillary liquid chromatography (TP-CLC), coupled off-line to solvent elimination FTIR (LC Transform ) has recently been used for gradient separations of Irganox 1010/1076/3114 dissolved in DMF with LOD of about 40 ng [511]. Low... [Pg.494]

T. Baczek and R. Kaliszan, Combination of linear solvent strength model and quantitative structure-retention relationships as a comprehensive procedure of approximate prediction of retention in gradient liquid chromatography. J. Chromatogr.A 962 (2002) 41-55. [Pg.59]

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Chromatography solvent gradients

Liquid gradient

Solvent liquids

Solvents gradients

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