Liquid chromatography peak capacity

Kovat s retention index (p. 575) liquid-solid adsorption chromatography (p. 590) longitudinal diffusion (p. 560) loop injector (p. 584) mass spectrum (p. 571) mass transfer (p. 561) micellar electrokinetic capillary chromatography (p. 606) micelle (p. 606) mobile phase (p. 546) normal-phase chromatography (p. 580) on-column injection (p. 568) open tubular column (p. 564) packed column (p. 564) peak capacity (p. 554)... 

Grushka, E. (1984). Effect of high speed on peak capacity in liquid chromatography. J. 

Jandera, P., Novotna, K., Kolarova, L., Fischer, J. (2004). Phase system selectivity and peak capacity in liquid column chromatography—the impact on two-dimensional separations. Chromatographia 60, S27. 

Gilar, M., Daly, A.E., Kele, M., Neue, U.D., Gebler, J.C. (2004). Implications of column peak capacity on the separation of complex peptide mixtures in single- and two-dimensional high-performance liquid chromatography. J. Chromatogr. A 1061, 183-192. 

At least two driving forces have contributed to the recent increased use and development of multidimensional liquid chromatography (MDLC). These include the high resolution and peak capacity needed for proteomics studies and the independent size and chemical structure selectivity for resolving industrial polymers. In this regard, separation science focuses on a system approach to separation as individual columns can contribute only part of the separation task and must be incorporated into a larger separation system for a more in-depth analytical scheme. 

This chapter illustrates possible applications of capillary electrophoresis in impurity profiling. Due to the large peak capacity of the technique, it is extremely well suited to separate the main drug compound from its possible impurities that often have a very related chemical structure. Moreover, the high efficiencies obtained, as well as the low reagent consumption make it a viable alternative to liquid chromatography in many cases of drug analysis. 

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