Liquid chromatography parallel mode

Tswett s initial column liquid chromatography method was developed, tested, and applied in two parallel modes, liquid-solid adsorption and liquid-liquid partition. Adsorption ehromatography, based on a purely physical principle of adsorption, eonsiderably outperformed its partition counterpart with mechanically coated stationary phases to become the most important liquid chromatographic method. This remains true today in thin-layer chromatography (TLC), for which silica gel is by far the major stationary phase. In column chromatography, however, reversed-phase liquid ehromatography using chemically bonded stationary phases is the most popular method. 

A number of valuable methods of analysis are essentially batch processis themselves and cannot be operated on a continuous basis. Their use in an on line mode will then require frequent sampling and rapid presentation of the sample to the instrument followed by rapid analysis. It may be necessary to use a battery of analysers working in parallel to cope with the number of samples presented. A particularly important example of batch analysis is the use of gas-liquid chromatography. The power of this technique to provide rapid analysis of complex mixtures has led to its use for "monitoring many organic processes, and its integration into many chemical plants. 

Another unique characteristic of this technology is the potential for online structure information collection. This HTP method utilizes a high-pressure chromatography system in a parallel processing mode, i.e., multiple simultaneous column runs coupled to a robot controlled liquid handling... 

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