Liquid chromatography open access

As FIA-MS and liquid chromatography mass spectrometry (LC-MS) become more pervasive in the analysis of compound libraries, open-access instrumentation is increasingly used in HTOS laboratories as well as in support of general medicinal chemistry. These open-access systems are most often used for reaction monitoring and optimization, and in some cases, for library quality control and synthesis product purification. 

Mallis, L.M. Sarkahian, A.B. Kulishoff Jr, J.M. Watts Jr., W.L. Open-access Liquid Chromatography/Mass Spectrometry in aDrug Discovery Environment, J. Mass Spectrom. 37, 889-896 (2002). 

Sinner FM, Buchmeiser MR. Ring-opening metathesis polymerization access to a new class of functionalized, monolitic sattionary phases for liquid chromatography. Angew Chem Int Ed 2000 39 1433-6. 

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