Lipschitz test

The Lipschitz test has been proven to be a standard method and a very useful tool for screening of potential diuretics. 

Remark 2 The e-convergence test are sufficient for e-improvement but they are not necessary. An additional condition, which is an inverse Lipschitz assumption, needs to be introduced so as to prove the necessity. This additional condition states that for points of a certain distance apart the value of the feasibility cut should differ by at least some amount. This is stated in the following theorem of Holmberg (1990). 

A method for testing diuretic activity in rats has been described by Lipschitz et al. (1943). The test is based on water and sodium excretion in test animals and compared to rats treated with a high dose of urea. The Lipschitz-value is the quotient between excretion by test animals and excretion by the urea control. 

Lipschitz et al. ( ) tested in dogs the exchangeability of the iron of monoferric phytate and the nonheme iron of a meal. 

---