Lipoxygenases INDEX

Peroxidase is used as a convenient index of lipase activity. The inactivation temperature for lipases and associated enzymes is dependent on the moisture content. At 4% moisture, inactivation temperature for lipoxygenase is 40°C, lipase is 55°C, and peroxidase is 70°C (28). 

Figure 13. Effect of extrusion temperature on protein dispersibility index (PDI) and lipoxygenase enzymes activity (LOX).

LIpoxins (LX). Acyclic eicosanoids with conjugated tetraene or pentaene structures and three hydroxy groups. The first identified compounds were designated as L. A and L. B with the index 4 or 5 to indicate the number of their C=C-double bonds. Biosyn-thetically L. are formed from arachidonic acid under the action of various oxidizing enzymes, especially 5- and 15-lipoxygenases. (55,6/J,155)-Trihydroxy-... 

Fig. 1.16 Network-like similarity graph (NSG) depicting the CS and activity relationships of a set of lipoxygenase inhibitors taken from the work of Wawer et al. [170], Compound potencies are color coded as shown by the colored bar on the upper left hand side of the figure, red being the most active and green being the least active. Compounds are connected by an edge if the MACCS Tanimoto similarity value of a given compound pair exceeds 0.65. The decimal numbers associated with clusters of compounds correspond to SAR Index scores (See text for additional details)...

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