Liposomes edge activator

Transfersomes, deformable liposomes, were introduced by Cevc et al. in the early 1990s [66-69]. The main components of these systems are phospholipids, a surfactant edge activator (such as sodium cholate), water and sometimes very low concentrations of ethanol (<7%) [66]. Transfersomes are prepared by the same methods as liposomes. The preparation process is usually followed by homogenization, sonication, or other mechanical means to reduce the size of the lipid vesicles. 

Transfersomes are vesicles prepared from lipids and an edge activator that might be a single-chain lipid or surfactant. The edge activator renders the vesicles elastic. As a result of the hydration force in the skin, elastic vesicles can squeeze through SC lipid lamellar regions [47], Transfersomes were much more effective than conventional liposomes when applied nonocclusively with respect to mass flow of lipid across the skin. After 8 h of transfersome application... 

Recently, for the transdermal delivery of drugs using carrier systems, attention has been focused on the development of transformable [284,285] or elastic vesicles [12], These vesicles are liposomes that contain surfactants or in general edge activators in addition to phospholipids in their lipid membranes (Figure 10), a fact that... 

El Maghraby GM, Williams AC, Barry BW (2004) Interactions of surfactants (edge activators) and skin penetration enhancers with liposomes. Int J Pharm 276(1-2) 143-161... 

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