Lipoprotein metabolism, effect exercise

The effects of coenzyme Q10 on coronary artery disease and chronic stable angina are modest but appear promising. A theoretical basis for such benefit could be metabolic protection of the ischemic myocardium. Double-blind, placebo-controlled trials have demonstrated that coenzyme Q10 supplementation improved a number of clinical measures in patients with a history of acute myocardial infarction (AMI). Improvements have been observed in lipoprotein a, high-density lipoprotein cholesterol, exercise tolerance, and time to development of ischemic changes on the electrocardiogram during stress tests. In addition, very small reductions in cardiac deaths and rate of reinfarction in patients with previous AMI have been reported (absolute risk reduction 1.5%). 

As discussed above, aerobic exercise produces numerous physiologic and metabolic changes in the body. Many of these changes are believed to be beneficial for prevention of heart disease. The effects on cardiopulmonary function were mentioned earlier and are clearly beneficial, as are the changes in body composition described in Chapter 9. Further, aerobic exercise appears to have positive effects on blood oholesterol and other lipids. These effects of exercise on the metabolism of lipids and the important transport particles called lipoproteins are discussed in Chapter 5. 

Thomas, T.R., Smith, B.K., Donahue, O.M., Altena, T.S., James-Kracke, M., and Sun, G. Y., Effects of omega-3 fatty acid supplementation and exercise on low-density lipoprotein and high-density lipoprotein subtractions. Metabolism, 53, 749-754, 2004. 

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