Lipoprotein, desialylation

AMG is synthesized primarily by hepatic parenchymal cells. Catabolism is via two primary routes once the thiol ester bond is spht, AMG—regardless of whether complexed to a protease— is rapidly removed by a hepatic receptor that also acts to remove low-density lipoprotein. Desialylated... 

Tertov VV, Kaplun VV, Sobenin lA, Orekhov AN. Low-density lipoprotein modification occurring in human plasma possible mechanism of in vivo lipoprotein desialylation as a primary step of atherogenic modification. Atherosclerosis 1998 138 183-195. 

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