Lipids and Prostanoids

and trifluoro derivatives of fatty acids have been prepared in regio- and stereoselective manners, in order to evaluate the gauche effect induced by fluorine atoms on the conformation of hydrocarbon chains and for enzymatic studies. 

Arachidonic acid is the biosynthetic precursor of metabolites (such as prostaglandins) that play a basic role in cell signal processes. Fluorine atoms have been introduced on the strategic oxidation sites of arachidonic acid in order to study the 

Fluorine atoms have been introduced mainly at the vinylic positions 5, 6, 8, and 9, the allylic positons 7,10,and 13, and the terminal positions 2,19,and20. Onlyafew significant examples of these numerous works are discussed here  

A convergent synthetic approach developed for 10,10-, 13,13-, and 20,20-difluoroarachidonic acids, based on the reactivity of disymmetric difluor- 

The instability of PGI2 under physiological conditions (fy2 = 5-10 min at pH = 7.4 and at 37°C) is connected with both the rapid oxidation of the lateral chain and the presence of the enol ether function. It is so unstable that its function as a vasodilator and 

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