Lipid whisker model

Fig. 13.2 The lipid whisker model. Cell membranes of senescent or apoptotic cells contain oxidized phospholipids with sn-2 oxidized fatty acid acyl chains protruding into the extracellular space. This conformation renders them accessible to interact with scavenger receptors and other pattern recognition receptors on the surface of probing macrophages of the innate immune system (Greenberg et al., 2008 Permission for use of this figure has been requested from The Journal of Biological Chemistry.)...

Catala, A. Lipid peroxidation modifies the picture of membranes from the Fluid Mosaic Model to the Lipid Whisker Model, 94( 1), 2012 101-9. 

FIGURE 3.25 The lipid whisker model. The oxidation of the polyunsaturated acyl chain phospholipids increases its polarity so that it can be excluded from the apolar phase of the mem rane. e chain, which is saturated, maintains the glycerophospholipid anchored in the membrane. 

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