Lipid mediators of inflammation

Eicosanoids are the lipid mediators of inflammation that are derived from fatty acids such as arachidonic acid (AA). AA can undergo metabolism through several pathways to generate a wide variety of lipid mediators, such as prostaglandins (by Cox pathway) and leukotrienes (by Lox pathway), which serve as important intra-and intercellular messengers. - ... [Pg.178]

All the compounds tested (theaflavin mixture, theaflavin monogallate, and theaflavin-3,3 -digallate) were effective in inhibiting ear edema and levels of inflammatory mediators in a dose-dependent manner. Theaflavin-related compounds were able to inhibit both the cytokines (peptide mediators of inflammation) and eico-sanoids (lipid mediators of inflammation). ... [Pg.182]

The release of at least three different injurious species from activated neutrophils has been reported lipid mediators of inflammation proteolytic enzymes and cationic proteins, and oxygen radicals. Following chemo-taxis of neutrophils to the lung capillaries and adhesion to the endothelial... [Pg.69]

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