Lipid absorption-promoting factor

LIPID ABSORPTION PROMOTING FACTOR ( Pere sini )... [Pg.113]

According to Peressini et al., oral administration to infants of glandular mucoprotein" causes improved fat absorption (P4). Blood lipids increase after feeding this material. The marked effect upon the lipids is not identical with that of vitamin B12, nor is it due to the B12 absorption-promoting effect of this mucoprotein. The relationship of this factor to that of Balfour is not known. [Pg.335]

ASBT has a complex regulatory system reflecting the importance of this transporter to bile-acid pool size and bile-acid synthesis rates. Hepatic nuclear factor la (HNF-la) is necessary for expression of ASBT as knockout mice showed no expression and had defective bile-acid transport.Conversely, FXR-null mice showed no difference in expression of ASBT, showing that FXR plays no part in regulation of ASBT. In man, HNF-la controls baseline promoter activity of the ASBT gene as the minimal construct with full promoter activity was found to have 3 HNF-la binding sites. These authors also showed that the promoter construct bound peroxisome proliferator activated receptor a (PPARa)/9 cis retinoic acid receptor heterodimer, demonstrating a link between bile-acid absorption and hepatic lipid metabolism mediated by PPARa. [Pg.32]

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