Lipase, soluble polymer-supported

The multipolymer enzymatic resolution of soluble polymer-supported alcohols 42 and 43 was achieved using an immobilised lipase from Candida Antarctica (Novozym 435). The R-alcohol was obtained in enantiomerically pure form (>99% ee) after its cleavage from the poly(ethylene) glycol (PEG) scaffold . The achiral hydantoin- and isoxazoline-substituted dispirocyclobutanoids 47 were produced using both solution and solid-phase synthesis <00JOC3520, OOCC1835>. 

Soluble Polymer-Supported Lipase-Mediated Acylation... 

There are several examples where catalytic active membranes have been developed with immobilized enzymes on a porous ceramic support (Belleville et al, 2001 Lozano et al, 2002). Research on Candida antarctica lipase immobilization has further improved the preparation of active membranes. Another hydrophilic and water-soluble polymer, polyethyleneimine (PEI), which has a high content of free primary aminos as a coating agent, allows for an increase in the number of potential centres for enzymatic attachment (Rios et ah, 2004). 

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