Linkers synthesis

THE ALLYLSILYL LINKER SYNTHESIS OF CATALYTIC BINDING OF ALKENES AND ALKYNES TO AND CLEAVAGE FROM ALLYLDIMETHYLSILYL POLYSTYRENE... 

Formylrifamycin was then attached to the solid support through hydra-zone formation. Under several cleavage conditions, it proved possible to obtain either 3-formylrifamycin or rifampicin in good to excellent yield. For example, in case of cleavage with acetone/1% HCl, the product is obtained in 80% overall yield over linker synthesis and connection/ disconnection (total six steps) [98]. 

Synthesis of iodoarenes Tj resin "traceless" linker synthesis of phenols, biaryls, alkyl arenes, azides, aromatic hydrazines, halides ester, azo compounds, cinnolines, benzotri azoles... 

Galoppini, E., Chebolu, B., Gilardi, R., and Zhang, W. (2001) Copper(I)-catalyzed [2 + 2] photocycloadditions with tethered linkers synthesis of syn-photodimers of dicyclopentadienes. Journal of Organic Chemistry, 66, 162-168. 

Solid-phase organic synthesis (SPOS) has been revolutionary in the quest to produce libraries of structurally diverse molecules both quickly and cheaply. The utility of benzyl and aryl vinyl sulfones in the traceless linker synthesis of amines... 

Cai, S. X. Glenn, D. J. Kanskar, M. Wybourne, M. N. Keana, J. F. W. Development of highly efficient deep-UV and electron beam mediated cross-linkers synthesis and photolysis of bis(perfluorophenyl) azides, Chem. Mater. 1994, 6, 1822-1829. 

Musilek, K., Holas, O., Kuca, K., Jun, D., Dohnal, V., Opletalova, V., Dolezal, M. (2007c). Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker - synthesis and evaluation of their reactivation activity against tabun and paraoxon-inbibited acetylcholinesterase. Biorg. Med. Chem. Lett. 17 3172-6. 

HYCRON Linker Synthesis of Anchor Conjngates and Resin Loading 0 1... 

M. Grathwohl and R. R. Schmidt, Solid phase synthesis of oligomannosides and of a lactosamine containing milk trisaccharide using a benzoate linker, Synthesis, 15 (2001) 2263-2272. 

Metzger, J.O., and U. Linker, Synthesis of Linear and Branched Perfluoroalkylated Carboxylic Acids by Radical Addition of PerfluoroaUcyl Iodides to Unsaturated Fatty Acids, Liebigs Ann. Chem., 209-216 (1992). 

Lin, R., Liu, N., Yang, Y. et al. 2009. Radioiodination of protein using 2,3,5,6-tetrafluorophenyl 3-(n/[Pg.141]

Linkers Synthesis and Structure of a Quasi-Planar Ptis Dendrimer Containing Five Clusters Connected by c-Alkynyl Spacers. Angew. Chem. Int. Ed., 42, 5990-5993. (d) Chin, C. S. Kim, M. Lee, H. Noh, S., and Ok, K. M. (2002). Regio- and Stereoselective C-C Bond Formation between Alkynes Synthesis of Linear Dienynes from Alkynes. Organometallics, 21, 4785-4793. (e) Bruce, M. I. Davy, J. Hall, B. C. van Galen, Y. Skelton, B. W., and White, A. H. (2002). Some Platinum(ll) Complexes Derived from Aromatie Alkynes. Appl. Organomet. Chem., 16, 559-568. 

Scheme 19 Allylic ester linker synthesis and cleavage...

Rosenbaum, C. and Waldmann, H. (2001) Solid phase synthesis of cyclic peptides by oxidative cydative deavage of an aryl hydrazide linker-synthesis of stylostatin 1. Tetrahedron Lett., 42, 5677-5680. 

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