Hycron linker

Allylic hydroxycrotyl-oligoethylene glyco-n-alkanoyl (HYCRON) linker 25 was applied to the synthesis of protected peptides and glycopep-tides [31]. HYCRON is stable to both acidic and basic conditions and is compatible with Boc- and Fmoc-based chemistry. The preparation of this novel linker is only two steps from commercially available materials. H YCRON linker can be cleaved under neutral conditions using Pd catalyst (Scheme 9). 

In the mid to late 1990s, Seitz and Kunzh described a new allylic linker called HYCRON in which a polyether chain is inserted between the allylic group and the carboxy group. The loading on the polymer is best achieved by the preformed handle approach, as outlined in Scheme 4. 

HYCRON Linker Synthesis of Anchor Conjngates and Resin Loading 0 1... 

Liebe and Kunz made further use of the HYCRON linker methodology in the construction of the a2-6 sialyl-TN antigen attached to a portion of the mucin MUCl repeat peptide [104] (O Scheme 20). 

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