Linker photo-labile

The library was linked to the solid support via the photo-labile linker (see Fig. 8.6) which was cleaved at the 337 nm of the nitrogen laser used in MALDI-TOF mass spectrometers (optimal wavelength for cleavage of linker is 365 nm).The linker facilitated the... 

Nicolaou [57] has reported the synthesis of a dodecasaccharide employing a p-hydroxybenzoic acid spacer group connected via a photo labile linker [3- (hydroxymethyl) -4-nitrophenol] to the resin (Scheme 20.16). Sugar mono- or oligomers... 

Solution-phase chemistry is simpler than solid-phase. Solid-phase synthesis has two extra variables the resin and linker. Unwanted reactions on either can cause major problems. The reactivity of the resin, normally polystyrene, is typically very low and not a major concern. Linkers, however, are designed to be broken, so they must have some level of reactivity. The cleavage conditions must be strictly avoided during all the synthetic steps. Because photochemical reactions are uncommon in mainstream synthesis, photo-chemically labile linkers are attractive in solid-phase synthesis. 

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