Ligularia fischeri

Kim, R.-G., K.-M. Shin, S.-K. Chun, et al., 2002. In vitro antiinflammatory activity of the essential oU from Ligularia fischeri var. Spiciformis in murine macrophage Raw 264.7 cells. Yakhak Hoechi, 46(5) 343-347. 

Of the rearranged eudesmanes, eremophilanes (216) are most prolific ( 150 derivatives). The subject was reviewed in 1977 (314). Two stereochemical classes, 239 and 240, have been recognized in principle, these are related to the eudesmane (222) and intermedeane types (225), respectively. The first member of this class to be characterized was eremophilone (241), which occurs in the wood oil of the Australian tree Eremophila mitchelli, along with other related compounds. This was the first terpene structure not consistent with the isoprene rule and Robinson (327) invoked a 1,2-methyl shift from a eudesmane precursor to rationalize this structure. (-)-Eremoligenol (242) is a component of roots of Ligularia fischeri, while isovalencenic acid (243) has been isolated from vetiver oil. (-h)-Nootkatone (244) was first isolated from the heartwood of Alaska-cedar... 

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